An in-silico human cell model reveals the influence of spatial organization on RNA splicing
Fig 2
A) The reaction scheme describing the formation of U1 and U2 splicing particles mapped on a cross-section of our in-silico HeLa cell [38, 39]. The four spherically-shaped regions in cyan color are Cajal bodies. B) Splicing reactions as implemented in our simulations. The reactions together with their corresponding rate constants are presented in Tables 2 and 3. Abbreviations are: Pol II (RNA polymerase II), Ex1 and 2 (Exon 1 and 2).