An in-silico human cell model reveals the influence of spatial organization on RNA splicing
Fig 1
A data-driven model for a 18-μm HeLa cell: A) the cytoplasmic components are: ER, mitochondria and Golgi (not included in the figure for clarity); and B) a nucleus containing nuclear pore complexes, Cajal bodies and nuclear speckles.
The cytosol, nuclear pore complexes, nuclear speckles, and Cajal bodies are directly involved in RNA splicing processes, whereas ER, mitochondria and Golgi apparatus provide excluded volume effects.