Comprehensive analysis of structural and sequencing data reveals almost unconstrained chain pairing in TCRαβ complex
Fig 4
Bayesian network (BN) of TCRαβ complex residues.
a. The graph of BN built with separately learned inter-chain contacts (shown in S4 Fig) whitelisted and residues that are not contacting according to contact frequency thresholding blacklisted. b. A density plot showing correlation between log-likelihood (LL) of BN for paired chains (y axis, computed using the network in a.) and sum of LLs of individual α and β chains for ith clonotype from PairSEQ dataset. In order to compute individual chain LLs two independent networks were built by removing inter-chain edges and separating α and β residue components of the BN.