In silico investigation of the mechanisms underlying atrial fibrillation due to impaired Pitx2
Fig 3
Antiarrhythmic effects of flecainide on action potentials (AP, Vm).
a, Comparison of APs of LA cells in the presence or absence of 2 μM Fle. The main AP parameters included RMP (b), overshoot (c), dVdtmax (d) and APD (e). Simulated effects of 2 μM Fle on all targets (f), and on INa (g), on Ikr (h) and on RyR (i) respectively. Blue arrows indicate delayed afterdepolarizations. Abbreviations: LA–left atrium; Fle–flecainide; RMP–resting membrane potential; dVdtmax−maximum upstroke velocity; APD–action potential duration; RyR–ryanodine receptor.