From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response
Fig 1
Coupling multiscale data to a multiscale mathematical model.
Upper: data from rat experiments including imaging at 5, 10, and 17 days post injection, circumscribed and quantified from serial MRI images, tissue slice image, spatial distribution of infected (green) and recruited (red) cells, and individual cell tracks. Lower: the multiscale model represents the imaging as a spatial density map, considers the gray and white matter distribution in the rat brain tissue, and tracks cell types (infected and recruited), measured cell phenotypes (actual proliferation and migration), potential cell phenotypes (maximal proliferation and migration), and the PDGF concentration field.