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Long-range correlation in protein dynamics: Confirmation by structural data and normal mode analysis

Fig 4

The shape factor correlates with the chain lengths of the proteins.

(A) Three proteins with similar chain lengths: (Left) The receptor-binding domain of T4 STF (PDB: 1OCY, s = 0.84, Q = 0.74); (Middle) Human Hsp90 protein (PDB: 3T0H, s = 1.77, Q = 0.65); and (Right) The DHR10 protein (PDB: 5CWG, s = 2.37, Q = 0.63). (B) For proteins at similar sizes (chain length 180 ≤ N < 220), the scattering plot (yellow dots), binned average (red dots) and the trend line (red line) of shape factor s vs. modularity Q are plotted. Besides, there are histograms of the shape factor s (right vertical) and modularity Q (top horizontal). (C) For all the proteins in our dataset, the 2D histogram (in the background) of s vs. N and the plot (in navy blue) of the most-probable shape factor s* vs. chain length N.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1007670.g004