Direct coupling analysis of epistasis in allosteric materials
Fig 4
Generative performance of DCA.
Fitness vs distance to consensus of configurations generated by the inferred model, following the representation of [40]. The sampling is done from P(σ) of Eq 4 (a Boltzmann-Gibbs probability distribution), whose parameters have been inferred via ACE + maximum likelihood (red cloud) or mfDCA (green cloud). Original high fitness configurations (black cloud) and random ones (blue) are added as a reference. Each cloud consists of 104 sequences and the drawn ellipse gives one standard deviation around the mean in both horizontal and vertical directions. Distances to consensus of ACE + maximum likelihood, mfDCA and random sequences are shifted by respectively +0.7, −0.7 and −1.3 for better visibility.