Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms
Fig 4
Temporal measurements made during executions of the Parent Model Mechanism.
Average amount of MitoD (A) and nonMD (B) within PP, M-Z, and PC bands. (C) Cumulative Necrosis-Triggered and Necrotic events (dashed curves) within the three bands. vHPCs that are Necrosis-Triggered become Necrotic following a Monte Carlo sampled Necrosis interval.