SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy
Fig 3
SynToxProfiler penalizes for toxicity of drug pairs while ranking top hits.
The efficacy, toxicity, and synergy matrices for the top drug pairs selected based on the highest STE score (clomiphene citrate and sertraline HCL, upper panel) and the highest synergy score (toremifene citrate and apilimod, lower panel). The synergy was calculated using the ZIP model implemented in SynergyFinder [21]. The square with dotted line denotes the 3x3 concentration range with the most synergistic area in the dose-response matrix.