SynToxProfiler: An interactive analysis of drug combination synergy, toxicity and efficacy
Fig 2
STE score considers both synergy and selective efficacy when prioritizing potent drug combinations.
(A) 3D surface shows increase in STE score with increasing synergy and selective efficacy scores across 77 antiviral combinations measured in Huh7 liver cell line infected with Ebola virus (the arrow marks the gradient of the increase in STE score). The 3D surface is fitted by a generalized additive model with a tensor product smooth, implemented in mgcv R package. The color gradient from blue to red represents the low to high STE score for drug combinations. (B) Scatter plot showing the overlap in the top hits selected on the basis of STE and Synergy (red), STE and selective efficacy(orange), and selective efficacy and synergy(blue) scores. The dotted vertical line denotes the overlap between the top 10% combinations selected based on any of the three scores.