SuperFreq: Integrated mutation detection and clonal tracking in cancer
Fig 6
Assessment of clonal structure in AML using SuperFreq without matched normal controls.
Clone scatter plots of four AML patients (as in Fig 5), generated without using the matched normal sample. We include the germline clone to illustrate how it absorbs germline variants, as well as some somatic variants that have high clonality in both samples. While this is done successfully in AML.080 and AML.110, the two other samples have a large number of variants designated as somatic that are not identified in the cancer-normal analysis. AML.084 and AML.110 identify clones at low clonality in both samples that are not seen in the cancer-normal analysis, shown in grey.