SuperFreq: Integrated mutation detection and clonal tracking in cancer
Fig 5
Assessment of clonal structure in AML using SuperFreq.
(A) Clone scatter plots of four AML patients. The VAF is shown for all somatic point mutations that are tracked by SuperFreq, coloured by the clone they are assigned to. Selected mutations are highlighted, including CNAs that are assigned a VAF of half of the clonality. Point size is used to indicate read depth, with larger points reflecting higher coverage. River plots and line plots showing the progression of the clones across the Diagnosis (Dx), sorted normal (N) and relapse (Rel) samples for (B) AML.084 and (C) AML.110. Key mutations are highlighted in the line plots.