SuperFreq: Integrated mutation detection and clonal tracking in cancer
Fig 2
Precision and recall of somatic SNV calling across 304 TCGA participants and 33 cancer types.
(A) Recall of somatic SNVs called by the other four callers. (B) Number of unique somatic calls generated by each caller. (C) Recall of coding somatic SNVs from SuperFreq without a matched normal, using SuperFreq cancer-normal analysis as truth. Violins from left: cancer sample alone without filtering on the germlineLike flag, cancer sample alone filtered on the germlineLike flag, cancer sample paired with an in-silico dilution of the cancer and matched normal between 10% and 90%, filtered on the germlineLike flag. (D) Number of false coding SNV calls in the same sample configurations.