A model for time interval learning in the Purkinje cell
Fig 3
Scheme of molecular interactions in the model.
The opening of IP3 receptors (IP3r) liberates calcium (Ca2+). Both calcium (Ca2+) and G alpha stimulatory protein (Gs) stimulate adenylyl cyclase in a synergistic manner. AC generates cAMP which activates PKA. PKA creates a positive feedback opening more IP3 receptors. Calcium also activates RGS proteins wich create a negative feedback through inhibition of Gs.