A model for time interval learning in the Purkinje cell
Fig 1
(A) Drawing of a Purkinje cell in the cat’s cerebellar cortex, by Santiago Ramón y Cajal. (B) Basic circuit in eyeblink conditioning. The Purkinje cell receives the conditioned stimulus (CS) through parallel fibers from granule cells. The unconditioned stimulus (US) arrives through the climbing fiber from the inferior olive. The Purkinje cell also receives inhibitory inputs from stellate cells. Purkinje cell output is inhibitory to the deep cerebellar nuclei (DCN), which by rebound firing activates motor neurons generating the conditioned response (CR).