Two-variable nullcline analysis of ionic general equilibrium predicts calcium homeostasis in ventricular myocytes
Fig 1
Structure of the computational ventricular rabbit cardiomyocyte model.
Panel (1): Scheme of the three-dimensional model where the cardiomyocyte is divided into thousands of 3d stacked Calcium Release Units (highlighted one in red). Panel (2): Depiction of the basic structure of the CaRUs showing the L-type Calcium Channels (LCC) in the vicinity of the Ryanodine Receptor (RyR), the SERCA pump and the Na-Ca Exchanger. The different states of the LCC and the RyR2 are also depicted. Panel (3): Typical cytosolic (orange) and SR (blue) free calcium transients in the rabbit ventricular model (described in Methods) at a voltage-clamped pacing rate of 2 Hz.