Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways
Fig 10
Nucleotides/Nucleosides allosteric binding.
Examples of RLMs that do not mediate binding of ligands are shown in rainbow, with typical binding site loops in magenta. (A) ADP (black stick, colored by element) binds to bovine glutamate dehydrogenase (PDB: 1NQT) in the inter-chain interface (second chain in white). N-terminal flavodoxin-like domain is in light pink and C-terminal Rossmann-like domain is in light blue. Pivot helix is in purple. R459 shown by purple sticks. (B) Two SAMs (black stick, colored by element) bind to threonine synthase (PDB: 2C2B) interdomain interface distant from the typical Rossmann-like domain (N-terminal domain, light blue) active site marked by the PLP cofactor (magenta stick). C-terminal RLM domain is in light pink. The rigid block is in purple.