Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways
Fig 6
(A) Ligands from RLM catalyzed reactions. Combined KEGG compounds and UniProt cofactors (colored and classified according to ClassyFire superclass in legend) by assigned EC reaction count (Y-axis, cutoff at 100, with total number for EC>100 indicated) are distributed across top 23 ECOD homology groups (X-axis). (B-H) Superpositions of representative domains from largest H-groups. Secondary structure shown only for one representative. RLM is colored in rainbow. Ligands shown as spheres. Each sphere corresponds to one atom of particular ligand. Spheres are colored according ligands superclasses in legend of panel A.