Functional analysis of Rossmann-like domains reveals convergent evolution of topology and reaction pathways
Fig 2
(A) The ratio of observed and expected frequencies of metabolic reactions defines over (ratio>1) and under (ratio<1) represented pathway categories for RLM enzymes. Asterisks denote significant values according to Fisher’s exact test (P < 0.05). (B) Reaction categories of ECOD RLM families are depicted as a pie chart: families without any assigned EC reactions (Null), families with a single EC reaction type (Singleton), families with similar chemistries, but different substrates (Heterogeneous substrate), and families with different chemistries (Heterogeneous reaction) (C) Distribution of EC reaction classes among all RLM ECOD families that have an EC number assignment.