Predicting colorectal cancer risk from adenoma detection via a two-type branching process model
Fig 1
Two-type branching process model of colorectal cancer progression.
Cells immigrate from a static population of colonic crypt stem cells (green cells) into the adenoma compartment A with rate μ1. Compartment A grows with rate b1 and decreases with rate d1. With rate μ2 adenoma cells generate malignant cells, M. Cancer compartment M grows with rate b2 and decreases with rate d2. The total number of cells in compartments A and M and time t are denoted A(t) and M(t), respectively.