Quantifying pluripotency landscape of cell differentiation from scRNA-seq data by continuous birth-death process
Fig 3
Differentiation landscape and differentiation paths for real datasets.
A, D are the LDD potential landscapes, B, E are the potential values plotted in the two-dimensional reduction space, and C, F are the differentiation paths. A-C use Xu’s dataset, which describes that hepatoblasts (cluster 1) differentiate into hepatocytes (cluster 3) and cholangiocytes (cluster 5). D-F use Furlan’s dataset and show that chromaffin cells (cluster 4) are generated from SCPs (cluster 1).