Quantifying pluripotency landscape of cell differentiation from scRNA-seq data by continuous birth-death process
Fig 2
Differentiation landscape, differentiation paths, and gene networks for simulated models.
A and B are the LDD potential landscape and differentiation paths using data from the simulated drift-diffusion process, in which samples/cells were clustered into four groups. C and D are the two-gene and six-gene regulatory networks for simulation, respectively. For the two-gene network, the potential landscape and differentiation paths for clusters are shown in E and F, respectively, where seven clusters were detected. Constant potential V for each cluster was computed by LDD, while the landscape is an illustration constructed by the method in Materials and methods.