Uncovering and characterizing splice variants associated with survival in lung cancer patients
Fig 5
Robustness of single threshold methods and NEEP.
(A) The central 50 ranks for the 100 simulations of each of the 181 significant splice variants are plotted as a shaded range according to their mean simulated rank, separately for the 5% simulations (red) and the 10% simulations. Each of these ranges correspond to an observed (non-simulated) rank, which is plotted as a dot along the same x-axis. The 5% simulation ranges have lower means of simulation rank than the 10% simulation ranges; thus the red dots are closer to the identity line. The maximum mean of the simulation rank is lower for the 5% simulations; thus the red shade ends much sooner than the blue shade. (B) The density plot of the observed vs. simulation pairs for the 181 significant splice variants.