A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology
Fig 7
Targeting IL-4 signaling axis in macrophages in tumor.
Simulated time-course expression of M1 and M2 markers when macrophages are subjected to (A-B) high IL-4 production (10x of original value), (C-D) high IL-4 production with IL-4/receptor blockade (90% decrease in the binding rate between IL-4 and its receptor), (E-F) high IL-4 production with STAT6 inhibition (90% decrease in the binding rate between STAT6 and activated IL-4 receptor complex), and (G-H) high IL-4 production with PHD inhibition (90% decrease in the binding rate between PHD and O2). Species name denoted with * means expression in high IL-4 production plus treatment (species name without * means expression in high IL-4 production alone). (A-H) Marker expression levels are normalized to their respective t = 0 values (e.g. normoxia, unstimulated). All simulation results are protein levels (except CXCL10 is mRNA level).