Network-based analysis of prostate cancer cell lines reveals novel marker gene candidates associated with radioresistance and patient relapse
Fig 2
Gene copy number alterations of DU145 and LNCaP.
Gene copy number profiles of DU145 (a) and LNCaP (b) comparing radioresistant to radiosensitive cell lines. Gene copy number alterations are quantified by log2-ratios of radioresistant versus radiosensitive and plotted in the chromosomal order of genes. Deviations of log2-ratios from zero (brown dashed line) indicate the presence of gene copy number alterations. Considered reduced (green dots below blue dashed line: log2-ratios < -0.1) or increased (red dots above blue dashed line: log2-ratios > 0.1) gene copy numbers in the corresponding radioresistant cell lines of DU145 and LNCaP are highlighted. Ends of chromosomes are marked by black dotted vertical lines. Unchanged genes on a chromosome are shown by alternating grey and black dots to further support the visual separation between chromosomes. An additional heatmap representation including comparisons of radioresistant and radiosensitive DU145 and LNCaP to normal reference DNA is shown in S2 Fig.