A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model
Fig 14
Work done by ion pumps as a function of distance from center.
Top: Maximum and time average of the work done by ion pumps (note the two different y-axis scales), in both neurons and glia (over 3 minute duration), as measured by averaging over concentric circles around on the spiral center. Region closer to the center of the spiral does significantly more work. Bottom: Increasing NMDA receptor expression causes much more work to be done near the center, with a smaller increase seen away from the center.