A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model
Fig 9
Influence of cell swelling on extracellular voltage.
We vary NMDAR permeability between 4.5 − 6 × 10−5cm/s along the y-axis. Each panel has a different value for hydraulic permeability (water flux). The top and bottom panel have a minimum extracellular space of 2.5% and 10% respectively. For small enough hydraulic permeability, the wave looks no different than a NaP driven wave with no/little NMDA receptor activity.