A computational study on the role of glutamate and NMDA receptors on cortical spreading depression using a multidomain electrodiffusion model
Fig 5
NMDA receptor feedback mechanism.
Summary of CSD dynamics of our model. Initiation due to NMDA receptor with propagation caused by the combination of interstitial glutamate and potassium diffusion. Neuronal swelling causes prolonged activation of NMDA receptors.