Differential regulatory network-based quantification and prioritization of key genes underlying cancer drug resistance based on time-course RNA-seq data
Fig 3
The reconstructed sensitive and resistant networks as well as the differential network.
(A) Sensitive GRN. (B) Resistant GRN. (C) The differential network. The genes are represented as circled nodes, and the activating and repressing interactions are represented as red arrows and blue lines, respectively. (D) Top 10 significantly enriched pathways involving genes in the differential network. Cell cycle and chromosome segregation were significantly enriched.