Bayesian inference of metabolic kinetics from genome-scale multiomics data
Fig 3
Inference on a medium-scale metabolic network with limited data.
(A) Schematic of a portion of the considered metabolic network corresponding to lysine biosynthesis. Reactions shown in green were experimentally determined to improve lysine yields. The allosteric regulation of lysC by SDAP (N-succinyl-L,L-2,6-diaminopimelate) inferred by the model is shown in gray. (B) Experimental vs posterior predictive distributions for lysine flux. Error lines extend to cover the 95% highest posterior density (HPD) interval. (C) Distributions of elasticities informed by the experimental results. Prior distributions for these elasticities are shown in light gray. The one allosteric elasticity confidently inferred is shown as the last entry. (D) Flux control coefficients for each reaction in the model. Prior distributions (light gray) are mostly centered around zero. Posterior distributions (dark gray) are highlighted in green if their 95% HPD does not overlap zero. All lines indicate 95% HPD ranges, dots indicate median.