Bayesian inference of metabolic kinetics from genome-scale multiomics data
Fig 1
Overview of the modeling framework.
(A) The stoichiometry of the reaction network is used to determine prior distributions for the elasticity parameters. (B) The elasticity parameters represented in matrix form, where the column outlined in orange corresponds to m1 in (A). (C) For a metabolite m1, the prior distribution has predominately negative support for reactions in which the metabolite is a product (rA), positive support for reactions in which the metabolite is a reactant (rB), and a zero-centered, sparsity inducing prior for reactions in which the metabolite does not participate (rC).