A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data
Fig 4
Fitting of the refined model to adipose tissue flux data measured at baseline and following caloric restriction from the Yoyo study.
The refined model was fit to postprandial adipose tissue flux measurements of (A) LPL mediated lipolysis of circulating triglycerides, (B) the fractional spill over of LPL derived NEFA, (C) infflux of glucose, and efflux of both (D) glycerol, and (E) NEFA to the adipose tissue at baseline and following a period of caloric restriction. Blue crosses indicate the mean adipose tissue flux at baseline, the red crosses show the mean flux following caloric restriction, error bars indicate the standard error of the respective means. Refined model prediction at baseline is shown in blue, and the model fit following the diet intervention is shown in red. Negative flux values indicate a net release of the metabolite from the adipose space, positive values indicate a net uptake.