A computational model of postprandial adipose tissue lipid metabolism derived using human arteriovenous stable isotope tracer data
Fig 2
Structure of refined mathematical model of adipose tissue metabolism.
The refined model of adipose tissue metabolism consists of a two compartmental model, describing dynamics between the plasma and a lumped interstitial adipose space. The insulin stimulated LPL lipolysis of circulating triglycerides releases glycerol and NEFA. The hydrolysed NEFA passes into the adipose space, with an insulin-dependent fraction spilling over into the plasma. The insulin inhibited lipolysis of the triglycerides stored within the adipose tissue releases NEFA and glycerol. It is assumed that this glycerol cannot be recycled within the adipose space and enters the plasma for transportation to the liver. Glucose passes into the adipose space at an insulin dependent and independent rate. Glucose is converted to G-3-P and provides the glycerol backbone necessary for re-esterification of NEFA for storage as triglyceride within the adipose space. Novel model terms, introduced in this analysis, are shown in red, existing models are shown in black. Reactions that are stimulated by insulin are depicted with a green insulin symbol. Reactions that are inhibited by insulin are shown with a red insulin symbol.