Ancestral reconstruction of protein interaction networks
Fig 2
A.) The distribution of Pearson’s correlation coefficient averaged over 32 co-fractionation experiments on human cell lines. The distribution for gold-standard interacting human protein pairs is barely distinguishable from non-interactors. B.) Error models parameters were manipulated to replicate typical experimental noise. The equilibrium frequencies of the two state, π0 and π1, can be tuned to replicate class-imbalance. The difference between the means δ, was changed to replicate weak signal. The mixture weights for the positive error model, λ1 and λ2, set the false negative rate.