Ancestral reconstruction of protein interaction networks
Fig 1
A.) Schematic of the phylogenetic latent variable model, with a continuous time Markov chain describing the evolution of network edges and an error model mapping the unobserved edge states to continuous, observed data. Input features, including correlation, distance, and hypergeometric probability features, were extracted from several high-throughput datasets, comprising over 16k mass spectrometry experiments B.) Time-calibrated phylogeny of the species analyzed here.