Molecular mechanisms of fentanyl mediated β-arrestin biased signaling
Fig 4
Docking and modelling of various fentanyl derivatives.
a-b, Docking and sidechain interactions of fentanyl, sufentanil, and alfentanil (a), and carfentanil, and remifentanil (b). Relative potencies (in-vivo ED50) are taken from ref [29] and are displayed as a fold-difference from fentanyl in the upper left corner of each panel. c-e, Modelling of various 3-cis alkyl groups. Relative potencies (in-vivo ED50) are taken from ref [31] and are displayed as a fold-difference from fentanyl. f, Docking and sidechain interactions of fentanyl derivatives bearing amide (Compound 4D [33]) or n-alkyl phenyl (Fen-Acry-PEO7 [32]) extensions. g, Modeling of fused-ring fentanyl derivatives.