On measuring selection in cancer from subclonal mutation frequencies
Fig 4
Comparison of formula (1) for the cumulative distribution of driver frequency and exact computer simulations.
On the y-axis we plot the probability that driver frequency is below a particular value. Error bars are standard errors of the mean (s.e.m.) obtained via bootstrapping. Parameters: a, b = b1 = 0.14, d = 0.13, c = 1.7, u = 10−5, M = 108; b, b = b1 = 0.14, d = 0.13, c = 1.5, u = 10−4, M = 108; c, b = b1 = 0.14, d = 0.13, c = 1.5, u = 10−5, M = 108; d, b = b1 = 0.14, d = 0.17, c = 1.9, u = 10−5, M = 108.