On measuring selection in cancer from subclonal mutation frequencies
Fig 3
Probability of detection of a subclonal driver for a wide range of driver mutation rates and growth rate advantages is always below 60%.
Contour plots depict the probability that a subclonal driver is in the detectable range (0.2 ≤ fsub ≤ 0.8) and thus able to skew the distribution of mutation frequencies expected from neutral evolution, for a, small; b, intermediate; and c, large tumor size. Parameter values for moderately growing tumor b = b1 = 0.14, r = 0.01. All rates are per day.