SourceSet: A graphical model approach to identify primary genes in perturbed biological pathways
Fig 3
Simulation study results under the alternative hypothesis in scenario 2 (top panel), in scenario 3 (middle panel), and in scenario 4 (bottom panel).
On the left, results based on the maximum likelihood estimate of the covariance matrix; on the right results based on the regularized estimate. Each subpanel corresponds to a different combination of sample size (columns) and intensity of dysregulation (rows). Inside subpanels, for each node v ∈ V, a stacked bar chart shows the percentage of Monte Carlo runs in which (red, primary set),
(orange, secondary set) and
(green). The Monte Carlo error is bounded above by 2.2%.