Loop analysis of blood pressure/volume homeostasis
Fig 3
Diagram depicting antagonistic regulatory effects on vasoconstriction consisting of AVP and ANP endocrine systems acting on crosstalking signal transduction pathways of VSM, and stretch receptors closing the loops.
Labels for functional agents are the following. AMI: actomyosin interaction; ANPR: atrial natriuretic peptide receptor; CaM: calmodulin; CPI-17: protein phosphatase 1 regulatory subunit 14A; GC: guanylate cyclase; GEF: guanine nucleotide exchange factor; Gq: Gq alpha subunits of heterotrimeric G proteins; G12/13: G12/G13 alpha subunits of heterotrimeric G proteins; IP3R: inositol trisphosphate receptor; MLC myosin light chain; MLCK: myosin light chain kinase; MLCP: myosin-light-chain phosphatase; PKG: cGMP-dependent protein kinase; PLC: phospholipase C; PMCA: plasmamembrane Ca2+-ATPase; RhoA: Ras homolog gene family member A small GTPase; ROCK: Rho-associated protein kinase; V1R vasopressin receptor 1. Labels for effect mediators and anatomical districts are the following. cGMP: cyclic guanosine monophosphate; IP3: inositol trisphosphate. Other labels and line endings as in Fig 1.