Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers
Fig 4
Differential response of SCLC subtypes to a wide variety of oncology drugs and investigational agents.
A. Ranked sensitivity of subtypes across 526 compounds. NEv2 is least sensitive for over half of the drugs tested. B. No significant differences can be seen in response to etoposide and platinum-based agents cisplatin and carboplatin, the standard of care for SCLC. C-F. Significantly differential response by ANOVA, p < 0.05, shown in drugs that target C. mTOR, D. HSP90, E. BRD2, and F. AURKA. NEv2 is significantly more resistant to all of these drugs.