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p¹³CMFA: Parsimonious ¹³C metabolic flux analysis

Fig 4

Comparison of the predictive power of ¹³C MFA, pFBA, GIMME, and p¹³CMFA.

A: Pearson’s correlation coefficients between the reference flux distribution and the flux maps obtained from ¹³C MFA (optimal solution), pFBA, GIMME, and p¹³CMFA. p¹³CMFA was applied both with and without integrating gene expression data (p¹³CMFA+ge and p¹³CMFA-ge, respectively). The statistical significance of the difference between correlation coefficients was evaluated using the Fisher r-to-z transformation[33]. B: Euclidian distances between the reference flux distribution and the flux maps obtained from ¹³C MFA (optimal solution), pFBA, GIMME, and p¹³CMFA.

doi: https://doi.org/10.1371/journal.pcbi.1007310.g004