A biophysical model of striatal microcircuits suggests gamma and beta oscillations interleaved at delta/theta frequencies mediate periodicity in motor control
Fig 3
FSI network rhythms change with background excitation and synaptic strength.
Power and frequency of δ/θ and γ rhythms in FSI network mean voltage as a function of (A) tonic input current, (B) gap junction conductance, and (C) GABAA conductance. The parameters not being varied in plots A-C are held at the high DA values (Iapp = 14 μA/cm2, gGJ = 0.3 mS/cm2, gsyn = 0.005 mS/cm2, τgaba = 13 ms. The solid line represents the mean value over 10 simulations per point. Shading represents standard deviation from these means. Power spectra are derived using Thomson’s multitaper power spectral density (PSD) estimate (MATLAB function pmtm). (D) Gamma frequency as a function of GABAa synaptic time constant and level of dopamine. High DA values are as previously stated; low DA values are Iapp = 7 μA/cm2, gGJ = 0.15 mS/cm2, gsyn = 0.1 mS/cm2.