Estimating information in time-varying signals
Fig 9
Multilevel mutual information estimates from single-cell time-series data for mammalian intracellular signaling.
Data replotted from Ref [26] for ERK (top row) and Ca2+ (bottom row). (A) Early transient responses after addition of 5 different levels of EGF for ERK (or 4 different levels of ATP for Ca2+, respectively) at t = 0 min, as indicated in the legend. (B) In the late response most, but not all, of the transients have decayed. (C,D) Information estimation using different methods (legend) in the early (C) and late (D) period, for ERK (left half of the panels) and Ca2+ (right half). Data for ERK: N = 1678 per condition, T = 30 min (d = 30) for early response and T = 30 min (d = 30) for late response. Data for Ca2+: N = 2995 per condition, T = 10 min (d = 200) for early response and T = 5 min (d = 100) for late response. Plotting conventions as in Fig 8.