DeepHiC: A generative adversarial network for enhancing Hi-C data resolution
Fig 6
Analysis of significant interactions identified using DeepHiC-enhanced Hi-C data of mouse early embryonic development.
(a) Heatmaps showing examples of original and DeepHiC enhanced contact matrices for various stage of embryonic development. (b) Fraction of significant interactions for which anchor loci intersected with gene promoters. Error bar: standard deviation. Significance: ***: p-value < 1 × 10−20 one-sample t-test. (c) Fraction of significant interactions for which both connected loci contain ATAC-seq signal peaks. Error bar: standard deviation. Significance: ***: p-value < 1 × 10−20, one-sample t-test. (d) A representative Hi-C contact matrix, with significant interactions as depicted for the 8-cell stage. Left panel: Original Hi-C contact matrix and predicted significant interactions (bold pixels inside red circles). Right panel: DeepHiC enhanced contact matrix and predicted significant interactions (blue pixels).