DeepHiC: A generative adversarial network for enhancing Hi-C data resolution
Fig 3
Genome-wide comparative analyses of similarity and correlation in various cell types.
(a) High SSIM scores between DeepHiC-enhanced and real high-resolution matrices for all chromosomes in the GM12878 dataset. (b) In extending this analysis to other cell lines, we calculated the differences SSIM scores derived from DeepHiC and baseline models. Circle dots represent the Δ values on each chromosome. Dotted line represents the location of zero value. (c) Comparison of Pearson correlation coefficients between non-experimental data and real Hi-C data at each genomic distance of interest from 50kb to 1Mb. DeepHiC outperforms other methods at all genomic distances examined. (d) We calculated all differences (Δ) between correlations derived from DeepHiC and those derived from HiCPlus/HiCNN at each distance in four datasets. The results obtained are depicted with boxplots. All Δ values are significantly greater than zero (dotted line) (paired t-test, pair number = 96). The whiskers are 5 and 95 percentiles. ***: p-value < 1x10-20.