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Size and structure of the sequence space of repeat proteins

Table 1

Entropies (in bits, i.e. units of ln(2)) of sequences made of two consecutive repeats, for the three protein families shown in Fig 1.

Entropies are calculated for models of different complexity: model of random amino acids (Srand = 2L ln(21), divided by ln(2) when expressed in bits); independent-site model (S1), pairwise interaction model (S2); pairwise interaction model with constraints due to repeat similarity λID (Sfull); pairwise interaction model of two non-interacting repeats learned without (Sir) and with (Sir,λ) constraints on repeat similarity. Fig 2 shows graphically some of the information contained in this table.

Table 1

doi: https://doi.org/10.1371/journal.pcbi.1007282.t001