Selective recruitment of cortical neurons by electrical stimulation
Fig 5
Different cell types have distinct preferences for stimulation type (anodal or cathodal).
(a-c) Dependence of the activation probability on the net electrode current I for excitatory cells (a), basket cells (b), Martinotti and bi-tufted cells (c). (d1,2) Anodal stimulation (d1) activates pyramidal cells LII/III more effectively than cathodal stimulation (d2). (e1,2) Pyramidal LIV/V and spiny stellate cells have no preference for any type of stimulation. Because of the rich axonal arborization in supragranular layers, both types of stimulation provide large activation area. (f1,2) Cathodal current is more effective in activation of non-myelinated horizontal axons of Martinotti cells in supragranular layers.