Benchmarking network propagation methods for disease gene identification
Fig 5
Ranking according to the predictions of the main explanatory models (left) and the reduced explanatory models within the STRING network and block cross-validation (right), in both cases on the drugs input and averaging over diseases. The main models serve as a global description of the metrics, whereas the reduced models are specific to the scenario of most interest. A column-wise z-score on the predicted mean is depicted, in order to illustrate the magnitude of the difference. Note how the top 20 hits and the AUPRC metrics lead to similar conclusions, as opposed to AUROC.