Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation
Fig 9
The effect of SCRE heterogeneity on the SR-Ca2+-TA relationship.
A–Dependence of single cell DADs (purple), single cell TA (blue), and ectopic focal activity in 2D tissue (green; square markers) on the SR-Ca2+ concentration in control (i) and reduced IK1 conditions (ii); homogeneous SCRE dynamics. B–Dependence of ectopic focal activity in tissue on SR-Ca2+ in the heterogeneous SRF conditions with small and large variability (blue and orange) and with small and large variability with higher SR-Ca2+ threshold cells reassigned to baseline (blue and red; triangular markers) compared to the homogeneous condition (green); single cell DADs in the baseline condition are shown for reference (purple).